Original Research

  • Silva AB, Leonard MK, Oganian Y, D'Esopo E, Krish D, Kopald B, Tran EB, Chang EF, Kleen JK. Interictal epileptiform discharges contribute to word-finding difficulty in epilepsy through multiple cognitive mechanisms. (2023). Epilepsia. PMID: 37753856.
  • Loube DK, Tan YL, Yoshii-Contreras J, Kleen J, Rao VR, Chang EF, Knowlton RC. Ictal EEG Source Imaging With Supplemental Electrodes. (2023). Journal of Clinicial Neurophysiology. PMID: 37820169.
  • Valdrighi A, Douglas A, Knowlton RC, Shah M, Kleen JK. Clinical Reasoning: A Young Adult with New Seizures and Chapeau de Gendarme. Neurology, 101(18):e1821-e1827. PMID: 37580161.
  • Hullett PW, Kandahari N, Shih TT, Kleen JK, Knowlton RC, Rao VR, Chang EF. Intact speech perception after resection of dominant hemisphere primary auditory cortex for the treatment of medically refractory epilepsy: illustrative case. (2022). Journal of Neurosurgery Case Lessons, 4(22). PMID: 36443954; PMCID: PMC9705521.
  • Kleen JK, Chung JE, Sellers KK, Zhou J, Triplett M, Lee K, Tooker A, Haque R, Chang EF. Bidirectional propagation of low frequency oscillations over the human hippocampal surface. (2021). Nature Communications, 12(1):2764. PMID: 33980852
  • Kleen JK, Speidel B, Baud MO, Rao VR, Ammanuel SG, Hamilton LS, Chang EF, Knowlton RC. Accuracy of omni-planar and surface casting of epileptiform activity for intracranial seizure localization. (2021). Epilepsia. 62(4):947-959. PMID: 33634855
  • Leguia MG, Rao VR, Kleen JK, Baud MO. Measuring synchrony in bio-medical timeseries. (2021). Chaos, 31(1):013138. PMID: 33754758
  • Andrews J, Ammanuel, SG, Kleen JK, Khambhati A, Knowlton RC, Chang EF. Early seizure spread and epilepsy surgery: a systematic review. (2020). Epilepsia, 61(10):2163-2172.
  • Ammanuel SG, Kleen JK, Leonard MK, Chang EF. (2020). Interictal Epileptiform Discharges and the Quality of Human Intracranial Neurophysiology Data. Frontiers Human Neuroscience, 14:44. PMID: 32194384
  • Chiang S, Goldenholz D, Moss R, Rao V, Haneef Z, Theodore W, Kleen JK, Gavvala J, Vannucci M, Stern J. (2020). Prospective Validation Study of an Epilepsy Seizure Risk System for Outpatient Evaluation. Epilepsia, 61(1):29-38. PMID: 31792970
  • Baud MO, Kleen JK, Mirro EA, Andrechak JC, King-Stevens D, Chang EF, & Rao VR. (2018). Multi-day rhythms modulate seizure risk in epilepsy. Nature Communications, 9(1):88. PMID: 29311566
  • Baud MO, Kleen JK, Anumanchipalli GK, Hamilton LS, Tan YL, Knowlton R, & Chang EF. (2017). Unsupervised learning of spatiotemporal interictal discharges in focal epilepsy. Journal of Neurosurgery, 83(4):683-691. PMID: 29040672.
  • Rao VR, Leonard MK, Kleen JK, Lucas BA, Mirro EA, & Chang EF. (2017). Chronic ambulatory electrocorticography from human speech cortex. NeuroImage, 153:273-282.
  • Kleen JK, Testorf ME, Roberts DW, Scott RC, Jobst BC, Holmes, GL & Lenck-Santini PP. (2016). Oscillation Phase locking and late ERP components of intracranial hippocampal recordings correlate to patient performance in a working memory task. Frontiers in Human Neuroscience, 10:287.
  • Thomas AA, Fisher JL, Rahme GJ, Hampton TH, Baron U, Olek S, Schwachula T, Rhodes CH, Gui J, Tafe LJ, Tsongalis GJ, Lefferts JA, Wishart H, Kleen J, Miller M, Whipple CA, de Abreu FB, Ernstoff MS, Fadul CE. (2015). Regulatory T cells are not a strong predictor of survival for patients with glioblastoma. Neuro-Oncology, 17(6):801-9.
  • Kleen JK, Scott RC, Holmes GL, Roberts DW, Rundle MM, Testorf M, Lenck-Santini PP, & Jobst BC. (2013). Hippocampal interictal epileptiform activity disrupts cognition in humans. Neurology, 81(1):18-24.
  • Kleen JK, Wu EX, Scott RC, Holmes GL, & Lenck-Santini PP. (2011). Enhanced oscillatory activity in the hippocampal-prefrontal network is related to short-term memory function after early-life seizures. Journal of Neuroscience, 31(43):15397-406.
  • Kleen JK, Sesque A, Wu EX, Miller FA, Hernan AE, Holmes GL, & Scott RC. (2011). Early-Life Seizures Produce Lasting Alterations in the Structure and Function of the Prefrontal Cortex. Epilepsy & Behavior, 22(2):214-9.
  • Isaev D, Zhao Q, Kleen JK, Lenck-Santini PP, Adstamongkonkul D, Isaeva E, & Holmes GL. (2011). Neuroaminidase reduces interictal spikes in a rat temporal lobe epilepsy model. Epilepsia, 52(3), e12-5.
  • Kleen JK, Valdés PA, Harris B, Holmes GL, Paulsen K, & Roberts DW. (2011). ALA-induced PpIX fluorescence in epileptogenic tissue. Proceedings of the SPIE (Photonic Therapeutics and Diagnostics VII), 7883:78833S1-7.
  • Kleen JK, Scott RC, Holmes GL, & Lenck-Santini PP. (2010). Hippocampal interictal spikes disrupt cognition in rats. Annals of Neurology, 67(2):250-7.
  • Kleen JK, Sitomer MT, Killeen PR, & Conrad CD. (2006). Chronic stress impairs spatial memory and motivation for reward without disrupting motor ability and motivation to explore. Behavioral Neuroscience, 120(4), 842-51.
  • Baran SE, Campbell AM, Kleen JK, Foltz CH, Wright RL, Diamond DM, Conrad CD. (2005). High-fat diet combined with psychosocial stress retracts hippocampal dendrites. Neuroreport, 16(1), 39-43.

Published Commentaries

  • Kleen JK, Guterman EL. (2023). The New Era of Automated Electroencephalogram Interpretation. JAMA Neurology. 80(8):777-778. PMID: 37338899.
  • Kleen JK, Davis KA. (2023). Is It Reasonable to Drive When There Is a (Spike) Train? Neurology. 101(9):377-379. PMID: 37414566.
  • Kleen JK & Kirsch H. (2017). The nociferous influence of interictal discharges on memory. Brain, 140(8):2072-2074.
  • Kleen JK & Lowenstein D. (2017). Advances in Epilepsy and Future Research Objectives. JAMA Neurology, 74(2):139-140.
  • Kleen JK & Holmes GL. (2010). Taming TLR4 may ease seizures. Nature Medicine, 16:369-370.
  • Kleen JK & Holmes GL. (2008). Brain inflammation initiates seizures. Nature Medicine, 14:1309-1310.

Book Chapters

  • Kleen JK & Rao VR. 2023. Managing neurostimulation for epilepsy. Marks Jr. & Ostrem (Ed.), Deep Brain Stimulation Management, 3rd Edition. Cambridge, UK: Cambridge University Press.
  • Kleen JK & Holmes GL. (2017). Disentangling the Role of Seizures and EEG Abnormalities in the Pathophysiology of Cognitive Dysfunction. Lagae (Ed.), Cognition and Behaviour in Childhood Epilepsy. London, UK: Mac Keith Press.
  • Kleen JK & Levin M. (2016). Injection Therapy for Headache and Facial Pain. Scrivani (Ed.), Oral and Maxillofacial Surgery Clinics of North America. Philadelphia, PA: Elsevier.
  • Kleen JK, Scott RC, Lenck-Santini PP, & Holmes GL. (2012). Cognitive and Behavioral Co-Morbidities of Epilepsy. In: Noebels, Avoli, Rogawski, Olsen, Delgado-Escueta (Eds.), Jasper's Basic Mechanisms of the Epilepsies, 4th edition. Bethesda, MD: Oxford University Press.