Kleen Lab

Overview

The Kleen Lab is based in the Division of Epilepsy, and Department of Neurology, at the University of California San Francisco (UCSF). Jon Kleen MD PhD is the principal investigator and a neurologist, epileptologist, and neuroscientist.

• We study the neural mechanisms of memory neurophysiology, particularly hippocampal circuits and semantic knowledge processing, and create open-source software tools for localizing and tracking seizures directly in brain tissue. 
• Our translational research program primarily utilizes human intracranial recordings as a data source.
• We apply neural signal processing, recent advances in AI/machine learning, and/or data visualization approaches for our investigations. 
• We strive to make new discoveries about memory and cognition in humans, and how neurological diseases disrupt these crucial functions. 

Central Initiatives:

We feel very fortunate to collaborate closely with leaders in human neurophysiology, bioengineering, computer science, and more at UCSF and other institutions. Together, we are advancing the understanding of neural processes that support the incredible cognitive abilities that define us as human beings, and developing new approaches to rescue them from disease.

Giants game, 2025

Lab hike to Lands End in San Francisco, 2025

Check out our PROJECTS page to learn more about select Kleen Lab initiatives, including:​

Seizure heatmap visualization (OPSCEA, or "Ictal Cinema")

Visual Semantic Association Task (ViSAT)

Hippocampal microgrids (traveling waves)

...and more

Looking for signal processing resources featured in the AES Signal Processing Investigator Workshop? 
"Extracting Neural Signals from Noise in Electrophysiological Data: Tools and Traps"

Workshop Contributors: Jon Kleen, Jeremy Barry, Tom Donoghue, Dora Hermes, Andrea Navas-Olive
All resources mentioned in this workshop and more can be found here, all open-source: AESsignalworkshop.github.io